Endocrine Abstracts

Venous thrombosis is a common disease, with an annual incidence of 1–4/1000 persons. Before menopause its incidence is low and strongly increases with age. Combined hormonal contraceptives (COC) increased the risk of VTE. COC use explains a substantial part of VTE among childbearing-aged women and VTE is the most important determinant of the benefit/risk profile of hormonal contraceptive. The increase in thrombotic risk is the highest the first year of COC use and third g...

Common carotid artery intima media thickness (CCA-IMT), aortic stiffness (carotid-femoral pulse wave velocity-PWV) and central pulse pressure (PP) are early markers of atherosclerosis. The influence of hormonal replacement treatment (HRT) on arterial parameters in menopausal women remains to be investigated.We used baseline data of 665 menopausal women with hypercholesterolemia, screened for the CASHMERE study, a 12-month double-blind randomized trial co...

Beta-blockers (BB) may be less effective than other antihypertensive drugs for stroke prevention in patients with primary hypertension (ASCOT and LIFE studies). Our study compares arterial stiffness and central PP between users (BB+) and non users of BB (BB-), among menopausal women with hypercholesterolemia and no history of CV disease.Methods and Results: We used the baseline data of 664 menopausal women, screened for the Cashmere study, a12-month doub...